Scientists have at last unveiled new functions of the hippocampus

on 01 October 2017
Riding the brain waves

This article is interesting, interesting because it gives a better understanding of the role and functioning of the hippocampus, a very important and valuable scientific milestone. It also should mean quite a bit for the hypnosis community too!

The hippocampus, the most studied part of the brain

This is important because hypnosis is the medium in which the client's brain activity hovers in the ranges of Theta and Delta brainwaves. Theta is where we do all of our dreamings, perhaps the seat of a part of our imagination? The hippocampus could be described as the gateway to memory, for everything that we remember passes through the hippocampus, some things are in working or short term memory and others are stored for the longer term, maybe forever?

Long term memories are stored in and throughout the cerebral cortex and the ability of hypnosis to allow the client access to those memories is the precursor of the change they seek. But access is only a part of the story. Once accessed, hypnotherapy allows the process of memory reconsolidation to occur. Reconsolidation is a process wherein memories can be re-written, changed, adapted etc. And it is these changes that allow the client to express their memories differently. Of course, when a memory expresses itself differently, you get a different outcome.

More often than not (but by no means always), when working with clients, the form of memory we are mostly changing is implicit memory. This could be described as your "habit" memory, e.g. tying your shoelaces, brushing your teeth, driving a car playing an instrument, typing etc. Similarly, there are elements of (habit) memory in many of the conditions clients seek help for, e.g. smoking, grinding teeth, bed-wetting, phobias even anxiety and stress are mostly memory-driven (from a disordered perspective).

This sort of research is of great value to me, because it adds weight to my theories of what is happening during hypnosis. Evidentially I know that hypnosis creates change, client testimonials are proof of that, but knowing that hypnosis works still doesn't tell you exactly how or why it works! Of course, this won't change the way I do hypnosis, it merely gives me greater confidence in the knowledge I have acquired over the past 17 or so years.

The Research:

A research team led by Lam Woo Professor of Biomedical Engineering Ed X. Wu of the Department of Electrical and Electronic Engineering at the University of Hong Kong has made major breakthrough in unveiling the mysteries of the brain to reveal functions of an important region, the hippocampus, not known to scientists before.

The findings have recently been published in the international academic journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) in August 2017.

The hippocampus, located underneath the cortex, plays important role in memory and navigation. Alzheimer's disease and other forms of dementia have been proven to have affected and damaged this area of the brain, resulting in early symptoms including short-term memory loss and disorientation. People with hippocampal damage may lose the ability to form and retain new memories. It is also closely related to other diseases such as epilepsy, schizophrenia, transient global amnesia and post-traumatic stress disorder.

However, the role of the hippocampus in complex brain networks, particularly its influence on brain-wide functional connectivity, is not well understood by scientists. Functional connectivity refers to the functional integration between spatially separated brain regions.

Rodent experiments conducted by Dr Russell W. Chan, Dr Alex T. L. Leong and others, led by Professor Wu, revealed that low-frequency activities in the hippocampus can drive brain-wide functional connectivity in the cerebral cortex and enhance sensory responses. The cerebral cortex is the largest region of the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness. In other words, low-frequency activities of the hippocampus can drive the functional integration between different regions of the cerebral cortex and enhance the responsiveness of vision, hearing and touch. These results indicated that the hippocampus can be considered as the heart of the brain, a breakthrough in our knowledge of how the brain works.

Furthermore, these results also suggest that low-frequency activities in the hippocampus can enhance learning and memory since low-frequency activities usually occur during slow-wave sleep which has been associated with learning and memory. Slow-wave sleep often referred to as deep sleep, is a state that we usually enter several times each night and is necessary for survival. Alzheimer's disease is a chronic neurodegenerative disease that usually starts slowly and worsens over time, and the most common early symptom is memory loss. These results may also have potential therapeutic implications for hippocampal neuro-modulation in Alzheimer's disease.

These current findings are a major step in furthering our fundamental understanding of the origins and roles of brain-wide functional connectivity. These findings also signify the potentials of rsfMRI and neuro-modulation for early diagnosis and enhanced treatment of brain diseases including Alzheimer's disease, dementia, epilepsy, schizophrenia, transient global amnesia, and post-traumatic stress disorder.

Professor Wu's team is one of the world's leading teams in functional magnetic resonance imaging (fMRI) research, particularly in the investigation of auditory and visual functions, and brain structural and functional connectivity. The pioneering technologies they employ include the use of optogenetics activation, pharmacological inactivation and fMRI to serve as an important tool for investigating the dynamics underlying brain activity propagation as well as the origins and roles of brain functional connectivity.

Their earlier revelation that the thalamus, another region connecting to the cortex, is not just a relay or passive brain region as initially thought, but can initiate brain-wide neural interactions at different frequencies, had been published in the December 2016 edition of PNAS.

The human brain is the source of our thoughts, emotions, perceptions, actions, and memories. How the brain actually works, however, remains largely unknown. One grand challenge for neuroscience in the 21st century is to achieve an integrated understanding of the large-scale brain-wide interactions, particularly the patterns of neural activities that give rise to functions and behaviour. In 2010, the National Institute of Health (NIH) in the US launched the Human Connectome Project which aims to "provide an unparalleled compilation of neural data, an interface to graphically navigate this data and the opportunity to achieve never before realised conclusions about the living human brain." In 2013, the Obama administration in the US launched the BRAIN Initiative to "accelerate the development and application of new technologies that will enable researchers to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits interact at the speed of thought." In November 2016, China launched its own initiative "The China Brain Project," which aims to advance basic research on the neural circuit mechanisms underlying cognition in hopes to improve brain disease diagnosis/intervention and inspire the development of brain-machine intelligence technology.

Major research findings:  Based on current knowledge, one expects the hippocampus to predominantly generate high-frequency activities and these activities are largely confined within the hippocampus. However, in this study, low-frequency optogenetic excitation of the dorsal dentate gyrus, a subregion of the hippocampus, evoked cortical and subcortical activities which are beyond the hippocampus. Furthermore, this low-frequency stimulation enhanced brain-wide functional connectivity in the bilateral hippocampus, visual cortex, auditory cortex and somatosensory cortex. Meanwhile, pharmacological inactivation of the hippocampus decreased brain-wide functional connectivity. In addition, visually evoked responses in visual regions also increased during and after such low-frequency hippocampal stimulation. Together, these experimental results highlight the role of low-frequency activity propagating along the hippocampal-cortical pathway, particularly its contribution to brain-wide functional connectivity and enhancement of sensory functions.

The human brain only accounts for 2% of the total body weight, yet it consumes about 20% of the total body's energy demand. Despite its importance, it is one of the least understood organs of the body. The research team's findings have advanced our fundamental understanding of the origins and roles of brain-wide functional connectivity.

Optogenetic and pharmacological functional magnetic resonance imaging:  The emerging integrated technique adopted by Professor Wu's team consists of optogenetics, pharmacological neuromodulation and functional magnetic resonance imaging (fMRI). Optogenetics is a neuromodulation method that uses a combination of techniques from optics and genetics to control the activities of individual neurons in living tissues. Pharmacological neuro-modulation uses drugs to manipulate the activities of neurons. fMRI is a large-view non-invasive imaging technique for detecting brain-wide activations. Researchers can make use of fMRI to visualize whole brain activity in response to different optogenetic stimulation and pharmacological manipulations. The synergistic combination of the three technologies has enormous potential to spark a new age of interdisciplinary research to advance our understanding of the brain.

Story Source:

Materials provided by The University of Hong KongNote: Content may be edited for style and length.

Journal Reference:

  1. Russell W. Chan, Alex T. L. Leong, Leon C. Ho, Patrick P. Gao, Eddie C. Wong, Celia M. Dong, Xunda Wang, Jufang He, Ying-Shing Chan, Lee Wei Lim, Ed X. Wu. Low-frequency hippocampal–cortical activity drives brain-wide resting-state functional MRI connectivityProceedings of the National Academy of Sciences, 2017; 114 (33): E6972 DOI: 10.1073/pnas.1703309114