A remarkable result on the role of one of the brain's glial (support) cells, astrocytes; the neural vacuum cleaners. This seems to be a real case of, prevention is always better than cure and with hypnotherapy, the cure is a very relaxing experience . . .
Too much stress changes the brain in a negative way!
Most people have heard of neurotransmitters, a few that come to mind are serotonin, dopamine acetylcholine and, as mentioned in this research, norepinephrine (noradrenaline). What is not so well advertised are glial cells, the brains support network. So it is really interesting to see the role these support cells play in exacerbating stress. This highlights the need to help clients manage their stress.
Another aspect that struck me, is, could this be the key to why some antianxiety medications are less effective for some patients? This is no doubt something that will be researched in tandem with the findings of this study but in the meantime, hypnotherapy is available to help manage stress. Of course, the other aspect of managing stress is, if you manage the stress, the brain can get on with its job of making life a pleasant and enjoyable experience!
Hypnotherapy stands out as one of the most effective strategic life management methods there is, especially in its ability to promote clear thinking and good states of mental wellness. The behaviours that make life challenging are often a result of too much stress, too little or poor quality sleep and too little by way of mental and emotional clarity! So, to get or take back control of your mind and your life, it makes perfect sense to use a methodology that addresses the subconscious brain's role in perpetuating negative, vague and ambiguous states of mind. Hypnosis helps us to create calm relaxing states of mind that make life work better! If you would like to address any concerns you have in this direction, or, if you just want the ability to make your life feel better, then why not make an appointment for a Free Consultation? Hypnosis gives you the ability to have a good life!
My objective is to help people understand how and why we become illogically trapped into emotional experiences that may actually be happening but for reasons, we may never have imagined! If you want to know more about Hypnotherapy, why not make an appointment for a Free Consultation?
Research led by Si-Qiong June Liu, MD, PhD, Professor of Cell Biology and Anatomy at LSU Health New Orleans School of Medicine, has shown how stress changes the structure of the brain and reveals a potential therapeutic target to prevent or reverse it. The findings are published in the Journal of Neuroscience.
Working in a mouse model, Liu and her research team found that a single stressful event produced quick and long-lasting changes in astrocytes, the brain cells that clean up chemical messengers called neurotransmitters after they've communicated information between nerve cells. The stressful episode caused the branches of the astrocytes to shrink away from the synapses, the spaces across which information is transmitted from one cell to another.
The team also discovered a mechanism resulting in communication disruption. They found that during a stressful event, the stress hormone norepinephrine suppresses a molecular pathway that normally produces a protein, GluA1, without which nerve cells and astrocytes cannot communicate with each other.
"Stress affects the structure and function of both neurons and astrocytes," notes Dr Liu. "Because astrocytes can directly modulate synaptic transmission and are critically involved in stress-related behaviour, preventing or reversing the stress-induced change in astrocytes is a potential way to treat stress-related neurological disorders. We identified a molecular pathway that controls GluA1 synthesis and thereby astrocyte remodelling during stress. This suggests new pharmacological targets for possible prevention or reversal of stress-induced changes."
She says that since many signalling pathways are conserved throughout evolution, the molecular pathways that lead to astrocyte structural remodelling and suppression of GluA1 production may also occur in humans who experience a stressful event.
"Stress alters brain function and produces lasting changes in human behaviour and physiology," Liu adds. "The experience of traumatic events can lead to neuropsychiatric disorders including anxiety, depression and drug addiction. Investigation of the neurobiology of stress can reveal how stress affects neuronal connections and hence brain function. This knowledge is necessary for developing strategies to prevent or treat these common stress-related neurological disorders."
- Christian Luis Bender, Xingxing Sun, Muhammad Farooq, Qian Yang, Caroline Davison, Matthieu Maroteaux, Yi-shuian Huang, Yoshihiro Ishikawa, Siqiong June Liu. Emotional stress induces structural plasticity in Bergmann glial cells via an AC5-CPEB3-GluA1 pathway. The Journal of Neuroscience, 2020; JN-RM-0013-19 DOI: 10.1523/JNEUROSCI.0013-19.2020
Cite This Page:
Louisiana State University Health Sciences Center. "How stress remodels the brain." ScienceDaily. ScienceDaily, 14 April 2020. <www.sciencedaily.com/releases/2020/04/200414122804.htm>.